The efficacy and tolerance of intranasal interferons: studies at the Common Cold Unit
Identifieur interne : 001D46 ( Main/Exploration ); précédent : 001D45; suivant : 001D47The efficacy and tolerance of intranasal interferons: studies at the Common Cold Unit
Auteurs : D. A. J. Tyrrell [Royaume-Uni]Source :
- Journal of Antimicrobial Chemotherapy [ 0305-7453 ] ; 1986.
Abstract
Intranasal sprays of interferons (IFNs) given one day before and for three days after virus challenge can protect human volunteers from infection with rhinoviruses, corona virus, and influenza. Longer dosage of IFN gives rise to nasal symptoms and signs such as bloodstained nasal discharge. More effective IFNs and regimes are therefore needed. IFNβ is active but the degree to which it will irritate the nose is unknown. Combining IFNs with synthetic antiviral drugs can produce synergistic increases in antiviral activity. It is suggested that these increases may be exploited in future experiments.
Url:
DOI: 10.1093/jac/18.Supplement_B.153
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000164
- to stream Istex, to step Curation: 000132
- to stream Istex, to step Checkpoint: 000715
- to stream Main, to step Merge: 001D69
- to stream Main, to step Curation: 001D46
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>The efficacy and tolerance of intranasal interferons: studies at the Common Cold Unit</title>
<author wicri:is="90%"><name sortKey="Tyrrell, D A J" sort="Tyrrell, D A J" uniqKey="Tyrrell D" first="D. A. J." last="Tyrrell">D. A. J. Tyrrell</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:0077763261C42E983E3613F4E9CE41A21A08074A</idno>
<date when="1986" year="1986">1986</date>
<idno type="doi">10.1093/jac/18.Supplement_B.153</idno>
<idno type="url">https://api.istex.fr/ark:/67375/HXZ-1543SRG0-R/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000164</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000164</idno>
<idno type="wicri:Area/Istex/Curation">000132</idno>
<idno type="wicri:Area/Istex/Checkpoint">000715</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000715</idno>
<idno type="wicri:doubleKey">0305-7453:1986:Tyrrell D:the:efficacy:and</idno>
<idno type="wicri:Area/Main/Merge">001D69</idno>
<idno type="wicri:Area/Main/Curation">001D46</idno>
<idno type="wicri:Area/Main/Exploration">001D46</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The efficacy and tolerance of intranasal interferons: studies at the Common Cold Unit</title>
<author wicri:is="90%"><name sortKey="Tyrrell, D A J" sort="Tyrrell, D A J" uniqKey="Tyrrell D" first="D. A. J." last="Tyrrell">D. A. J. Tyrrell</name>
<affiliation wicri:level="2"><country>Royaume-Uni</country>
<placeName><region type="country">Angleterre</region>
</placeName>
<wicri:cityArea>MRC Common Cold Unit, Harvard Hospital, Salisbury Wiltshire</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Journal of Antimicrobial Chemotherapy</title>
<title level="j" type="abbrev">J Antimicrob Chemother</title>
<idno type="ISSN">0305-7453</idno>
<idno type="eISSN">1460-2091</idno>
<imprint><publisher>Oxford University Press</publisher>
<date when="1986-10">1986</date>
<biblScope unit="vol">18</biblScope>
<biblScope unit="issue">Supplemet_B</biblScope>
<biblScope unit="page" from="153">153</biblScope>
<biblScope unit="page" to="156">156</biblScope>
</imprint>
<idno type="ISSN">0305-7453</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0305-7453</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Intranasal sprays of interferons (IFNs) given one day before and for three days after virus challenge can protect human volunteers from infection with rhinoviruses, corona virus, and influenza. Longer dosage of IFN gives rise to nasal symptoms and signs such as bloodstained nasal discharge. More effective IFNs and regimes are therefore needed. IFNβ is active but the degree to which it will irritate the nose is unknown. Combining IFNs with synthetic antiviral drugs can produce synergistic increases in antiviral activity. It is suggested that these increases may be exploited in future experiments.</div>
</front>
</TEI>
<affiliations><list><country><li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
</region>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Tyrrell, D A J" sort="Tyrrell, D A J" uniqKey="Tyrrell D" first="D. A. J." last="Tyrrell">D. A. J. Tyrrell</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D46 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001D46 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= CovidV2 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:0077763261C42E983E3613F4E9CE41A21A08074A |texte= The efficacy and tolerance of intranasal interferons: studies at the Common Cold Unit }}
This area was generated with Dilib version V0.6.33. |